Can inhaling sharpies make you high?

According to NIDA’s scientists, the answer is yes. Permanent markers contain chemicals called solvents. When inhaled, these solvents can produce a “high.” Like alcohol, inhalants including Sharpies can cause slurred speech, lack of coordination, euphoria, and dizziness. Unfortunately, the chemicals that cause these effects can also make you sick, kill your brain cells, and damage your nerves.